Anti-GPRC5D Antibody (7K15)
Referência NB-64-124836-100uL
Tamanho : 100uL
Marca : Neo Biotech
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Anti-GPRC5D Antibody (7K15)
(Synonyms: GPRC5D) Copy Product InfoSynonyms: GPRC5D
Catalog No. TMAY-02843 Copy Product Info
Anti-GPRC5D Antibody (7K15) is a Mouse antibody targeting GPRC5D. Anti-GPRC5D Antibody (7K15) can be used in ELISA,FCM.
For research use only—not for human use. No sales to individuals. Use as intended only.
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-GPRC5D Antibody (7K15) is a Mouse antibody targeting GPRC5D. Anti-GPRC5D Antibody (7K15) can be used in ELISA,FCM. |
| Synonyms | GPRC5D |
| Ig Type | Mouse IgG2b |
| Clone | 7K15 |
| Reactivity | Human |
| Specificity | Human GPRC5D |
| Verified Activity | 1. Flow cytometric analysis of Human GPRC5D expression on CHO-K1-transfected Cells were stained with purified anti-Human GPRC5D, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. 2. Measured by its binding ability in a functional ELISA. Immobilized Human GPRC5D-VLP protein at 5 μg/mL (100 μL/well) can bind GPRC5D Antibody, Mouse MAb, the EC50is 0.5-5 ng/mL. The VLP isotype control Protein is the negative control. |
| Application | ELISA FCM |
| Recommended Dose | ELISA: 1:1000-1:2000; FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human GPRC5D. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Orphan G-protein-coupled receptor family C group 5 member D (GPRC5D) has seven transmembrane segments forming the core of the receptor, as well as an intracellular C-tail and an extracellular N-terminal domain. GPRC5D is highly and selectively expressed on the surface of CD138+ multiple myeloma (MM) cells, whereas in normal tissues, a much lower expression is limited to plasma cells and certain hard keratinizing tissues. This makes GPRC5D a promising marker for monitoring tumor load and a target antigen for MM-specific T cell-engaging therapies such as bispecific antibodies and CAR-T cells. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human GPRC5D Protein |
| Antigen Species | Human |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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