Nav1.1 Na+ channel (sodium channel, voltage-gated, type I, alpha subunit/ SCN1A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn1a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.1 Na+ channel is a sodium selective channel that maintains Na+ homeostasis by allowing Na+ ions to pass in accordance of their electrochemical gradient. The protein plays an important role in the release of neurotransmittors from the neurons. Therefore, Nav1.1 Na+ channel is involved in the perception of mechanical pain due to the activation of sematosensory neurons without the involvement of inflammation. Mutation of the gene encoding for Nav1.1 Na+ channel is one of the main cause of epilepsy and febrile seizures.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
K74/71
IgG1
ELISA, ICC, IHC, IP, WB
Mouse
Scn1a
220 kDa
Fusion protein amino acids 1929-2009 (cytoplasmic C-terminus) of rat Nav1.1 (accession number P04774) produced recombinantly in E. Coli
Rat
Human, Mouse, Non-Human Primate, Rat
AB_2238842
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4
WB: 1:500 IHC: 1:250 ICC: 1:250
Unconjugated
No cross-reactivity with Nav1.2, Nav1.3 and Nav1.6
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1)
