Anti-Mouse CD4 Antibody (GK1.5)

Anti-Mouse CD4 Antibody (GK1.5) is a monoclonal inhibitory antibody targeting mouse CD4, with the biological activity of efficiently depleting CD4⁺ T cells in vivo. In xenograft model experiments, Anti-Mouse CD4 Antibody (GK1.5) can effectively prolong the survival of grafts and is therefore widely used in related mechanism studies in the field of immunology.

Anti-Mouse CD4 Antibody (GK1.5), administered as a single intraperitoneal injection at a dose of 0.2 mg on day 0 to female BALB/c (H-2d) mice, can significantly increase the proportion of peripheral regulatory T cells and simultaneously reduce the number of Treg cells in the thymus [1].
Anti-Mouse CD4 Antibody (GK1.5), administered to C57BL/6J mice inoculated with 2×10⁵ B16F10 melanoma cells on days 4 and 10, can successfully establish a mouse model of vitiligo [2].
Anti-Mouse CD4 Antibody (GK1.5), administered intraperitoneally at a dose of 5 mg/kg on days -8 and 6 and combined with OVA peptide vaccine in C57BL/6 mice bearing EG7 tumors, can effectively inhibit tumor metastasis and alter the number of T cells in mice [3].
Anti-Mouse CD4 Antibody (GK1.5), administered intraperitoneally at a dose of 0.2-5.4 mg on days -1, 1, 3, 7 and 10 to male CBA/H (H-2k) mice, can significantly prolong the survival time of porcine pre-islet xenografts by depleting CD4⁺T cells [4].

GK1.5

Mouse

Monoclonal

Unconjugated