Aucubin [479-98-1]
Referência T3416-50mg
Tamanho : 50mg
Marca : TargetMol
Aucubin (Synonyms: Rhinanthin, Aucuboside)
Aucubin
Copy Product InfoSynonyms Rhinanthin, Aucuboside
Cas No. 479-98-1
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.83%
Color:White to Red
Product Introduction
Aucubin AI Summary
Aucubin exhibits a range of bioactivities, including inhibiting the classical complement pathway activation at 4 µM with significantly higher inhibition (89.3%) in the presence of beta glucosidase. It demonstrates potent inhibition of L3MBTL1 (63.1 nM) and induces DNA re-replication (183.6 nM) in SW480 colon adenocarcinoma cells. The compound also shows estrogenic activity at the ERalpha in human MVLN cells with activities of 81.25% and 99.1% at concentrations of 100 µg/mL and 20 µg/mL, respectively, compared to E2. It inhibits electric eel Acetylcholinesterase (AChE) and horse Butyrylcholinesterase (BChE) at 2 mg/mL, although the inhibition percentages are modest (-1.28% for AChE and -12.67% for BChE). Additionally, it exhibits moderate to high inhibitory activity against the COX1 enzyme (48.2% to 50.2%) but weaker activity against the COX2 enzyme (below 30%). It shows no significant cytotoxicity against various human cancer cell lines (IC50 > 10000 nM) and demonstrates minimal inhibitory effects against SARS-CoV-2 3CL-Pro protease (0.17% at 20 µM). Lastly, it exhibits 0.14% inhibition of SARS-CoV-2-induced cytotoxicity in VERO-6 cells at 10 µM concentration after 48 hours..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities. |
| Synonyms | Rhinanthin, Aucuboside |
| Molecular Weight | 346.33 |
| Formula | C15H22O9 |
| Cas No. | 479-98-1 |
| Smiles | OCC1OC(OC2OC=CC3C(O)C=C(CO)C23)C(O)C(O)C1O |
| Relative Density. | 1.61 g/cm3 |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: 0.12 mg/mL (0.35 mM), Sonication is recommended  H2O: Insoluble |
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.77 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. |