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> c-Kit/CD117 Protein, Human, Recombinant (hFc)

c-Kit/CD117 Protein, Human, Recombinant (hFc)

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Referência NB-64-52790-200ug

Tamanho : 200ug

Marca : Neo Biotech


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c-Kit/CD117 Protein, Human, Recombinant (hFc)

(Synonyms: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, Tyrosine-protein kinase Kit, SCFR, Proto-oncogene c-Kit, Piebald trait protein, PBT, p145 c-kit, Mast/stem cell growth factor receptor Kit, KIT, CD117) Copy Product Info

Synonyms: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, Tyrosine-protein kinase Kit, SCFR, Proto-oncogene c-Kit, Piebald trait protein, PBT, p145 c-kit, Mast/stem cell growth factor receptor Kit, KIT, CD117

Catalog No. TMPJ-00402 Copy Product Info
C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction.
Other Forms of c-Kit/CD117 Protein, Human, Recombinant (hFc):
c-Kit/CD117 Protein, Mouse, Recombinant (His)
c-Kit/CD117 Protein, Human, Recombinant (His & Avi), Biotinylated
c-Kit/CD117 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)
c-Kit/CD117 Protein, Mouse, Recombinant (hFc)
c-Kit/CD117 Protein, Mouse, Recombinant (His)
c-Kit/CD117 Protein, Human, Recombinant (His)
c-Kit/CD117 Protein, Rat, Recombinant (hFc)
c-Kit/CD117 Protein, Rat, Recombinant (His)
c-Kit/CD117 Protein, Human, Recombinant (aa 50-190, His)
c-Kit/CD117 Protein, Human, Recombinant (hFc)
c-Kit/CD117 Protein, Human, Recombinant (aa 540-972, His & GST)
c-Kit/CD117 Protein, Rhesus, Recombinant (hFc)
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Information

Bioactivity
Bioactivity
Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction.
Species
Human
Expression System
HEK293 Cells
TagC-hFc
Accession NumberP10721
Amino AcidGln26-Thr520
ConstructionGln26-Thr520
Protein Purity
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
ReconstitutionReconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonymsv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, Tyrosine-protein kinase Kit, SCFR, Proto-oncogene c-Kit, Piebald trait protein, PBT, p145 c-kit, Mast/stem cell growth factor receptor Kit, KIT, CD117
Research Background
C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction.
Chemical Properties
Molecular Weight100-140 kDa (reducing condition)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageLyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

CD-117CD 117
Related Tags: c-Kit/CD117 Protein, Human, Recombinant (hFc) chemical structure | c-Kit/CD117 Protein, Human, Recombinant (hFc) molecular weight