CD45 / LCA Rat Monoclonal Antibody [Clone ID: RA3-6B2]
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SKU
SM034LE
CD45 / LCA rat monoclonal antibody, clone RA3-6B2, Low Endotoxin
Size:
100 ug
Conjugation:
Unconjugated
View other "Ptprc" antibodies
Specifications
Product Data
Clone Name
RA3-6B2
Application
FC, FN, IF, IHC, IP
Recommended Dilution
Flow cytometry. Immunoprecipitation. Immunohistochemistry on paraffin sections. Immunohistochemistry on frozen sections. Immnocytochemistry. Functional application: modulation of B cell responses.
This antibody recognizes an epitope on CD45R, which is expressed at all developmental stages of B cells, including activated B cells, but also on subsets of NK and T cells.T cells detected by this antibody are supposed to be in activated state.
CD45R, also known as B220, is a receptor-type protein tyrosine phosphatase glycoprotein. It is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45R expression also identifies a subset of murine bone marrow cells able to form osteoclast-like cells.
Synonyms
PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data
Protein Categories
ADC Targets, CD Markers, Cytokines, Growth Factors, Immune system diseases, Intracellular Proteins, Membrane Proteins
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
