Tamanho : 5mg
Synonyms:
| Description | Cholesterol (Water Soluble) is a water-soluble cholesterol preparation used in experimental studies to investigate the specific effects of cholesterol enrichment or depletion on the biophysical properties and functional characteristics of inner hair cells (IHCs) with regard to potassium currents. As an essential component of the plasma membrane, cholesterol has the ability to modulate the activity and kinetics of ion channels embedded in the lipid bilayer. (Note: This product is a mixture of cholesterol and methyl-β-cyclodextrin.) |
| Storage | Keep away from moisture,Keep away from direct sunlight, Store at 4°C Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: 40 mg/mL, Sonication is recommended. DMSO: ≥ 25 mg/mL |
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL, Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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