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> Dasiglucagon [1544300-84-6]

Dasiglucagon [1544300-84-6]

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Referência HY-P3469

Tamanho : Onrequest

Marca : MedChemExpress


Description

Dasiglucagon is a human glucagon analog, and can increase plasma glucose. Dasiglucagon can be used in hypoglycemia research[1][2][3].

In Vivo

Dasiglucagon PK profile shows a dose-dependent and rapid increase in plasma levels[2].

Dasiglucagon dose
0.1 mg 0.3 mg 0.6 mg 1.0 mg
N 5 16 16 16
AUC0–30min (pmol*h/L) 99.4 (32.0) 302 (78.9) 444 (163) 884 (307)
AUC0–360min (pmol*h/L) 451 (123) 1360 (166) 1630 (368) 4800 (697)
AUC0–inf (pmol*h/L) 451 (123) 1360 (166) 2640 (365) 4810 (696)
Cmax (pmol/L) 334 (113) 976 (208) 1570 (445) 2800 (767)
tmax (h) 0.50 (0.5-0.6) 0.63 (0.3-0.8) 0.58 (0.5-1.7) 0.63 (0.3-0.8)
t1/2 (h) 0.43 (0.07) 0.43 (0.07) 0.49 (0.14) 0.54 (0.17)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Essai clinique
Masse moléculaire

3381.62

Formule

C152H222N38O50
CAS No.
Sequence

His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-{Aib}-Ala-Arg-Ala-Glu-Glu-Phe-Val-Lys-Trp-Leu-Glu-Ser-Thr
Sequence Shortening

HSQGTFTSDYSKYLD{Aib}ARAEEFVKWLEST
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références