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> Dasiglucagon (acetate)

Dasiglucagon (acetate)

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Referência HY-P3469A-25mg

Tamanho : 25mg

Marca : MedChemExpress


Description

Dasiglucagon acetate is a human glucagon analog, and can increase plasma glucose. Dasiglucagon can be used in hypoglycemia research[1][2][3].

In Vivo

Dasiglucagon PK profile shows a dose-dependent and rapid increase in plasma levels[2].

Dasiglucagon dose
0.1 mg 0.3 mg 0.6 mg 1.0 mg
N 5 16 16 16
AUC0–30min (pmol*h/L) 99.4 (32.0) 302 (78.9) 444 (163) 884 (307)
AUC0–360min (pmol*h/L) 451 (123) 1360 (166) 1630 (368) 4800 (697)
AUC0–inf (pmol*h/L) 451 (123) 1360 (166) 2640 (365) 4810 (696)
Cmax (pmol/L) 334 (113) 976 (208) 1570 (445) 2800 (767)
tmax (h) 0.50 (0.5-0.6) 0.63 (0.3-0.8) 0.58 (0.5-1.7) 0.63 (0.3-0.8)
t1/2 (h) 0.43 (0.07) 0.43 (0.07) 0.49 (0.14) 0.54 (0.17)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Essai clinique
Masse moléculaire

3441.67

Formule

C154H226N38O52
Appearance

Solid

Color

White to off-white

Sequence Shortening

HSQGTFTSDYSKYLD{Aib}ARAEEFVKWLEST (acetate)
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvant et solubilité
In Vitro: 

H2O : 16.67 mg/mL (4.84 mM; ultrasonic and adjust pH to 3 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2906 mL 1.4528 mL 2.9056 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation
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