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> ENTPD2 Protein, Human, Recombinant (aa 29-460, His)

ENTPD2 Protein, Human, Recombinant (aa 29-460, His)

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Referência NB-64-58021-100ug

Tamanho : 100ug

Marca : Neo Biotech


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ENTPD2 Protein, Human, Recombinant (aa 29-460, His)

(Synonyms: RP11-229P13.11-001, NTPDase-2, ectonucleoside triphosphate diphosphohydrolase 2, CD39L1) Copy Product Info

Synonyms: RP11-229P13.11-001, NTPDase-2, ectonucleoside triphosphate diphosphohydrolase 2, CD39L1

Catalog No. TMPY-02929 Copy Product Info
NTPDase 2, also known as ENTPD2, belongs to the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). Members of E-NTPDase family are nucleotidases able to hydrolyze 5′-nucleoside tri- and/or diphosphates; the main role of these enzymes is the termination of purinergic signaling. NTPDases are ubiquitous and were previously shown in other parasites including the trypanosomatides of genus Leishmania and in T. brucei. NTPase activity would act as a timer and is crucial to T. gondii infection. In L. pneumophila it was demonstrated that an E-NTPDase, similar to CD39, is essential for intracellular bacterial multiplication. NTPDase 2 is an integral membrane protein. In the nervous system, it could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Alternative splicing of NTPDase 2 gene results in multiple transcript variants.
Other Forms of ENTPD2 Protein, Human, Recombinant (aa 29-460, His):
CD39L1 Protein, Mouse, Recombinant (His)TMPJ-00682
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:94.9%
Appearance:Solution
Color:Transparent
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Product Introduction

Bioactivity
Bioactivity
Measured by its ability to hydrolyze the 5’phosphate groups from the substrate adenosine 5’triphosphate(ATP). The specific activity is > 5,000 pmoles/min/μg.
Description
NTPDase 2, also known as ENTPD2, belongs to the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). Members of E-NTPDase family are nucleotidases able to hydrolyze 5′-nucleoside tri- and/or diphosphates; the main role of these enzymes is the termination of purinergic signaling. NTPDases are ubiquitous and were previously shown in other parasites including the trypanosomatides of genus Leishmania and in T. brucei. NTPase activity would act as a timer and is crucial to T. gondii infection. In L. pneumophila it was demonstrated that an E-NTPDase, similar to CD39, is essential for intracellular bacterial multiplication. NTPDase 2 is an integral membrane protein. In the nervous system, it could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Alternative splicing of NTPDase 2 gene results in multiple transcript variants.
Species
Human
Expression System
Baculovirus Insect Cells
TagN-His
Accession NumberQ9Y5L3
ConstructionA DNA sequence encoding the mature form of human ENTPD2 (Q9Y5L3) (Thr29-Asp460) was expressed, with a polyhistidine tag at the N-terminus. Predicted N terminal: His
Protein Purity
> 85 % as determined by SDS-PAGE
ENTPD2 Protein, Human, Recombinant (aa 29-460, His)
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationSupplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4.
ReconstitutionA Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
SynonymsRP11-229P13.11-001, NTPDase-2, ectonucleoside triphosphate diphosphohydrolase 2, CD39L1
Research Background
NTPDase 2, also known as ENTPD2, belongs to the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). Members of E-NTPDase family are nucleotidases able to hydrolyze 5′-nucleoside tri- and/or diphosphates; the main role of these enzymes is the termination of purinergic signaling. NTPDases are ubiquitous and were previously shown in other parasites including the trypanosomatides of genus Leishmania and in T. brucei. NTPase activity would act as a timer and is crucial to T. gondii infection. In L. pneumophila it was demonstrated that an E-NTPDase, similar to CD39, is essential for intracellular bacterial multiplication. NTPDase 2 is an integral membrane protein. In the nervous system, it could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Alternative splicing of NTPDase 2 gene results in multiple transcript variants.
Chemical Properties
Molecular Weight49.3 kDa (predicted); 59 kDa (reducing conditions)
Storage & Solubility Information
ShippingProteins are shipped with blue ice.
StorageIt is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Related Tags: ENTPD2 Protein, Human, Recombinant (aa 29-460, His) chemical structure | ENTPD2 Protein, Human, Recombinant (aa 29-460, His) molecular weight