OUR ESR1 probe is designed to detect ESR1 amplifications and deletions. The probe comes labeled in orange, but can be customized to meet your needs. 

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Gene Summary

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]

Gene Details

Gene Symbol: ESR1

Gene Name: Estrogen Receptor 1

Chromosome: CHR6: 152011630-152424408

Locus: 6q25.1-q25.2

References

Customer Publications

There are currently no FISH related publications for this gene.