Fenoprofen calcium salt [53746-45-5]

Fenoprofen calcium salt hydrate is a complex chemical compound that belongs to the class of chemicals known as carboxylic acids. The primary structure of fenoprofen is based on a propionic acid backbone, but it also contains a phenyl group and a naphthalene ring, which contribute to its aromaticity. When fenoprofen forms a salt with calcium, two fenoprofen molecules are ionically bonded to a single calcium ion, balancing the charge. The term "hydrate" in its name indicates the presence of water molecules that are associated with the compound, typically through relatively weak hydrogen bonds. The presence of these water molecules can impact the compound′s physical properties, such as its solubility and crystal structure. The resulting compound, fenoprofen calcium salt hydrate, has distinct chemical behavior and properties influenced by its complex structure and the presence of calcium and water.

References:

1. Chiral inversion of R(−) fenoprofen and ketoprofen enantiomers in cats.  |  Castro, E., et al. 2000. J Vet Pharmacol Ther. 23: 265-71. PMID: 11106999
2. Multiresidue analysis of acidic and polar organic contaminants in water samples by stir-bar sorptive extraction-liquid desorption-gas chromatography-mass spectrometry.  |  Quintana, JB., et al. 2007. J Chromatogr A. 1174: 27-39. PMID: 17727869
3. Effect of n-octanol in the mobile phase on lipophilicity determination by reversed-phase high-performance liquid chromatography on a modified silica column.  |  Benhaim, D. and Grushka, E. 2008. J Chromatogr A. 1209: 111-9. PMID: 18814882
4. Investigating the chlorination of acidic pharmaceuticals and by-product formation aided by an experimental design methodology.  |  Quintana, JB., et al. 2010. Water Res. 44: 243-55. PMID: 19800649
5. Characterization of Ascentis RP-Amide column: Lipophilicity measurement and linear solvation energy relationships.  |  Benhaim, D. and Grushka, E. 2010. J Chromatogr A. 1217: 65-74. PMID: 19939395
6. Anti-nociceptive activity and toxicity evaluation of Cu(II)-fenoprofenate complexes in mice.  |  Gumilar, F., et al. 2012. Eur J Pharmacol. 675: 32-9. PMID: 22169772
7. Hyphenation of ionic liquid albumin glassy carbon biosensor or protein label-free sensor with differential pulse stripping voltammetry for interaction studies of human serum albumin with fenoprofen enantiomers.  |  Abd El-Hady, D. and Youssef, AK. 2013. Anal Chim Acta. 772: 68-74. PMID: 23540249
8. Oxidation of non-steroidal anti-inflammatory drugs with aqueous permanganate.  |  Rodríguez-Álvarez, T., et al. 2013. Water Res. 47: 3220-30. PMID: 23582668
9. Enhanced analgesic properties and reduced ulcerogenic effect of a mononuclear copper(II) complex with fenoprofen in comparison to the parent drug: promising insights in the treatment of chronic inflammatory diseases.  |  Agotegaray, M., et al. 2014. Biomed Res Int. 2014: 505987. PMID: 25050353
10. A supramolecular topical gel derived from a non-steroidal anti-inflammatory drug, fenoprofen, is capable of treating skin inflammation in mice.  |  Majumder, J., et al. 2015. Org Biomol Chem. 13: 2300-9. PMID: 25554116
11. The pharmacokinetics of oral ketoprofen in patients after gastric resection.  |  Porażka, J., et al. 2017. Pharmacol Rep. 69: 296-299. PMID: 28178590
12. Fate of five pharmaceuticals under different infiltration conditions for managed aquifer recharge.  |  Silver, M., et al. 2018. Sci Total Environ. 642: 914-924. PMID: 29929143
13. Influence of obesity on pharmacokinetics and analgesic effect of ketoprofen administered intravenously to patients after laparoscopic cholecystectomy.  |  Porażka, J., et al. 2020. Pharmacol Rep. 72: 763-768. PMID: 32048255
14. Effect of Substitution Degree and Homogeneity on Cyclodextrin-Ligand Complex Stability: Comparison of Fenbufen and Fenoprofen Using CD and NMR Spectroscopy.  |  Kraszni, M., et al. 2023. Int J Mol Sci. 24: PMID: 37108706
15. A liquid chromatographic method for the determination of fenoprofen in equine plasma and urine.  |  Delbeke, FT. and Debackere, M. 1994. Biomed Chromatogr. 8: 29-31. PMID: 8130630