Formaldehyde dehydrogenase is a widely occuring enzyme that can catalyze S-hydroxymethylglutathione in the presence of NAD. Formaldehyde dehydrogenase detoxifies formaldehyde within cells through capturing and limiting it from reaching a toxic level. Formaldehyde dehydrogenase can be studied in research on M. tuberculosis^[1][2].

Instructions
When the product is placed at 37°C for 7 days, the enzyme activity loss is ≤10% (powder), and the activity will be inhibited by N²⁺, Pd²⁺, Hg²⁺, 4-chloromercuric benzoic acid and fluorophenylmethylsulfonyl.
It is easily soluble in water, but the solution is unstable. It is recommended to prepare it for immediate use. The optimum pH is 7.3-7.6. Reversible inactivation occurs when the solution is at pH 5.0, and irreversible inactivation occurs above pH 9.0.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

• [1]. Wani, S. R., & Jain, V. (2022). Molecular dissection of a dedicated formaldehyde dehydrogenase from Mycobacterium smegmatis. Protein science : a publication of the Protein Society, 31(3), 628-638.  [Content Brief]

  [2]. Koivusalo, M., et al., (1989). Evidence for the identity of glutathione-dependent formaldehyde dehydrogenase and class III alcohol dehydrogenase. FEBS letters, 257(1), 105-109.  [Content Brief]