Reagentes e instrumentos para imunologia, biologia celular e biologia molecular.
 
> Glutathione Oxidized

Glutathione Oxidized

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Referência M9343-1g

Tamanho : 1g

Marca : AbMole Bioscience

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Glutathione Oxidized Structure
Synonym:

GSSG

Quality Control & Documentation
Biological Activity

Glutathione oxidized is produced by the oxidation of glutathione

Chemical Information
Molecular Weight 612.63
Formula C20H32N6O12S2
CAS Number 27025-41-8
Solubility (25°C) Water ≥ 10 mg/mL
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nur E, et al. Biochim Biophys Acta. Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes.