Hamartin/TSC1 Polyclonal Antibody, PerCP-Cy7 Conjugated
Referência bs-3837R-PerCP-Cy7
Tamanho : 100ul
Marca : Bioss
Hamartin/TSC1 Polyclonal Antibody, PerCP-Cy7 Conjugated
Applications
Reactivity
Predicted Reactivity
Overview | |
Catalog # | bs-3837R-PerCP-Cy7 |
Product Name | Hamartin/TSC1 Polyclonal Antibody, PerCP-Cy7 Conjugated |
Applications | WB |
Reactivity | Sheep |
Predicted Reactivity | Human, Mouse, Rat, Dog, Cow, Pig, Horse |
Specifications | |
Conjugation | PerCP-Cy7 |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human Hamartin |
Immunogen Range | 131-230/1164 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target | |
Gene ID | 7248 |
Swiss Prot | Q92574 |
Subcellular location | Cytoplasm, Cell membrane |
Synonyms | LAM; TSC1; Tuberous sclerosis 1 protein; TSC1_HUMAN. |
Background | Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m(TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology. |
Application Dilution | |
WB | 1:300-5000 |