HCN4 antibody

Referência orb148492-100ug

Tamanho : 100ug

Marca : Biorbyt

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    HCN4 antibody

    HCN4 antibody

    Catalog Number: orb148492

    Catalog Numberorb148492
    CategoryAntibodies
    DescriptionMouse monoclonal to HCN4 (ATTO-488). Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels. Specifically, hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both the heart and brain.
    Species/HostMouse
    ClonalityMonoclonal
    Clone NumberN114/10 (Formerly sold as S114-10)
    Tested applicationsAM, FACS, ICC, IHC, WB
    ReactivityHuman, Mouse, Rabbit, Rat
    IsotypeIgG1
    ImmunogenFusion protein amino acids 1019-1198 (c-terminus) of rat HCN4
    Concentration1 mg/ml
    Dilution rangeWB (1:1000), IHC (1:1000), ICC/IF (1:100)
    ConjugationATTO-488
    MW130kDa
    TargetHCN4
    Entrez59266
    UniProt IDQ9JKA7
    NCBINP_067690.1
    StorageConjugated antibodies should be stored at 4°C
    Buffer/PreservativesPBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
    Alternative namesHyperpolarization activated cyclic nucleotide gate
    NoteFor research use only
    Application notes1 µg/ml of SMC-320 was sufficient for detection of HCN4 in 10 µg of COS cell lysate transiently transfected with HCN4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
    Expiration Date12 months from date of receipt.