Human FATP1 (Fatty Acid Transport Protein 1) Sandwich ELISA Kit E0008800)

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	SLC27A1
Gene ID:	376497
Uniprot ID:	S27A1_HUMAN
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver. Expressed in brain gray matter.
Post Translational Modifications
Function	Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Probably involved in fatty acid transport across the blood barrier.
Protein Name	Long-Chain Fatty Acid Transport Protein 1 Arachidonate--Coa Ligase Fatty Acid Transport Protein 1 Fatp-1 Long-Chain-Fatty-Acid--Coa Ligase Solute Carrier Family 27 Member 1 Very Long-Chain Acyl-Coa Synthetase
Database Links	Reactome: R-HSA-1989781 Reactome: R-HSA-804914
Cellular Localisation	Cell Membrane Single-Pass Membrane Protein Endomembrane System Cytoplasm Plasma Membrane And Intracellular Membranes At Least In Adipocytes In Adipocytes But Not Myocytes Insulin Via The Mtorc1 Signaling Pathway Induces A Rapid Translocation Of Slc27a1 From Intracellular Compartments To The Plasma Membrane Paralleled By Increased Lcfa Uptake Insulin-Dependent Translocation From The Cytoplasm To The Cell Membrane Is Regulated By Eprs1 Predominantly Cytoplasmic In Myocytes
Alternative ELISA Names	Long-Chain Fatty Acid Transport Protein 1 ELISA kit Arachidonate--Coa Ligase ELISA kit Fatty Acid Transport Protein 1 ELISA kit Fatp-1 ELISA kit Long-Chain-Fatty-Acid--Coa Ligase ELISA kit Solute Carrier Family 27 Member 1 ELISA kit Very Long-Chain Acyl-Coa Synthetase ELISA kit SLC27A1 ELISA kit ACSVL5 ELISA kit FATP1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance