ICK Antibody
Referência MBS856636-0,1mL-AF647
Tamanho : 0.1mL(AF647)
Marca : MyBiosource
Peptide-+
Peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ICK antibody. Immunofluorescence analysis of HeLa cells, using ICK antibody.
ICK Antibody
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS856636MBS856636 is an antibody targeting ICK. Also known as ICK Antibody. Reactive in Human, Mouse, Rat. More details
Product Overview
Online Datasheet in PDFProduct Name
ICK, Antibody
Full Product Name
ICK Antibody
Product Gene Name
anti-ICK antibody
Product Synonym Names
EC 2.7.11.22; ICK; Intestinal cell kinase; KIAA0936; LCK2; Laryngeal cancer kinase 2; MAK-related kinase; MRK; Serine/threonine kinase ICK; hICK; kinase ICK
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
ICK antibody detects endogenous levels of total ICK protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
34,071 Da
OMIM
612325
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human ICK.
Product Categories/Family for anti-ICK antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ICK antibody
Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-ICK antibody
IHC: 1:50-1:100
IF: 1:100-1:500
ELISA: 1:1000
IF: 1:100-1:500
ELISA: 1:1000
Product References and Citations for anti-ICK antibody
Togawa K., J. Cell. Physiol. 183:129-139(2000). Mungall A.J., Nature 425:805-811(2003). Nagase T., DNA Res. 6:63-70(1999).
Other Notes
Small volumes of anti-ICK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for ICK. It may not necessarily be applicable to this product.
NCBI Official Full Name
serine/threonine-protein kinase ICK
NCBI Official Synonym Full Names
intestinal cell kinase
NCBI Official Symbol
ICK
NCBI Official Synonym Symbols
ECO; MRK; LCK2; EJM10
UniProt Protein Name
Serine/threonine-protein kinase ICK
UniProt Synonym Protein Names
Intestinal cell kinase; hICK; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MRK
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
ICK
UniProt Synonym Gene Names
KIAA0936; hICK; LCK2; MRK
NCBI Protein Information
serine/threonine-protein kinase ICK
NCBI Summary for ICK
Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for ICK
Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (). May play a key role in the development of multiple organ systems and particularly in cardiac development (). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity ().
Show more Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Diseases associated with anti-ICK antibody
| Disease Name | Pubmed Publications |
|---|---|
| Neoplasms Antibodies | >18 publications with ICK and Neoplasms |
| Nervous System Diseases Antibodies | >6 publications with ICK and Nervous System Diseases |
| Pain Antibodies | >5 publications with ICK and Pain |
| Carcinoma Antibodies | >5 publications with ICK and Carcinoma |
| Lymphatic Diseases Antibodies | >4 publications with ICK and Lymphatic Diseases |
| Drug Toxicity Antibodies | >4 publications with ICK and Drug Toxicity |
| Inflammation Antibodies | >3 publications with ICK and Inflammation |
| Breast Neoplasms Antibodies | >3 publications with ICK and Breast Neoplasms |
| Mental Disorders Antibodies | >2 publications with ICK and Mental Disorders |
| Cell Transformation, Neoplastic Antibodies | >2 publications with ICK and Cell Transformation, Neoplastic |
Organs/Tissues associated with anti-ICK antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Eye Antibodies | >13 publications with ICK and Eye |
| Liver Antibodies | >7 publications with ICK and Liver |
| Brain Antibodies | >7 publications with ICK and Brain |
| Muscle Antibodies | >5 publications with ICK and Muscle |
| Bone Antibodies | >5 publications with ICK and Bone |
| Intestine Antibodies | >5 publications with ICK and Intestine |
| Vascular Antibodies | >4 publications with ICK and Vascular |
| Kidney Antibodies | >3 publications with ICK and Kidney |
| Skin Antibodies | >3 publications with ICK and Skin |
| Prostate Antibodies | >2 publications with ICK and Prostate |