LOXL2 Recombinant Antibody, PE-Cy7 Conjugated
Referência bsm-54163R-PE-Cy7
Tamanho : 100uL
Marca : Bioss
Applications
Reactivity
| Overview | |
| Catalog # | bsm-54163r-pe-cy7 |
| Product Name | LOXL2 Recombinant Antibody, PE-Cy7 Conjugated |
| Applications | WB |
| Reactivity | Human |
| Specifications | |
| Conjugation | PE-Cy7 |
| Host | Rabbit |
| Source | Synthetic peptide within Human LOXL2 aa 750 to the C-terminus |
| Clonality | Recombinant |
| Isotype | IgG |
| Concentration | Lot dependent |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 4017 |
| Swiss Prot | Q9Y4K0 |
| Subcellular location | Nucleus, Secreted, Endoplasmic reticulum |
| Synonyms | Lysyl oxidase homolog 2; Lysyl oxidase-like protein 2; Lysyl oxidase-related protein 2; Lysyl oxidase-related protein WS9-14; LOXL2; |
| Background | Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating the expression of factors that control chondrocyte differentiation. |
| Application Dilution | |
| WB | 1:500-2000 |