MAGIC RED CATHEPSIN K KIT
Referência MBS239218-25
Tamanho : 25Tests
Marca : MyBiosource
Staining of staurosporine-induced THP-1 cells using the Magic RedTM Cathepsin K kit
Cathepsin K (CTSK) Assay Kit
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS239218Description: The Magic Red Cathepsin K kit uses a quick and easy method to analyze intracellular Cathepsin K protease activity in whole living cells.Test Principle: Cathepsin Magic Red kits measure cathepsin K protease activity by detecting active cathepsins… More details
Product Overview
Online Datasheet in PDFProduct Name
CATHEPSIN K (CTSK), Assay Kit
Full Product Name
MAGIC RED CATHEPSIN K KIT
Product Gene Name
CTSK assay kit
Form/Format
Kit
Preparation and Storage
Store the unopened kit (and each unopened component) at 4 degree C until the expiration date.
Protect the MR-(LR)2 reagent from light at all times.
Once reconstituted, the 260X MR-(LR)2 stock should be stored at -20 degree C protected from light.
Shelf Life: The 260X MR-(LR)2 reconstituted stock is stable for up to 6 months and may be thawed twice during that time.
Protect the MR-(LR)2 reagent from light at all times.
Once reconstituted, the 260X MR-(LR)2 stock should be stored at -20 degree C protected from light.
Shelf Life: The 260X MR-(LR)2 reconstituted stock is stable for up to 6 months and may be thawed twice during that time.
Molecular Weight
36,966 Da
OMIM
265800
Reagents In The Kits
Magic Red MR-(LR)2 Reagent - lyophilized
Hoechst 33342 Stain, 1 mL
Acridine orange (AO), 0.5 mL
Hoechst 33342 Stain, 1 mL
Acridine orange (AO), 0.5 mL
Applications Tested/Suitable for CTSK assay kit
Immunofluorescence (IF)
Other Notes
Small volumes of CTSK assay kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for CTSK purchase
MBS239218 is an assay kit targeting CTSK. Also known as MAGIC RED CATHEPSIN K KIT.
Additional Details
NCBI/Uniprot data below describe general gene information for CTSK. It may not necessarily be applicable to this product.
NCBI Official Full Name
cathepsin K preproprotein
NCBI Official Synonym Full Names
cathepsin K
NCBI Official Symbol
CTSK
NCBI Official Synonym Symbols
CTSO; PKND; PYCD; CTS02; CTSO1; CTSO2
UniProt Protein Name
Cathepsin K
UniProt Synonym Protein Names
Cathepsin O; Cathepsin O2; Cathepsin X
Protein Family
Cathepsin
UniProt Gene Name
CTSK
UniProt Synonym Gene Names
CTSO; CTSO2
UniProt Entry Name
CATK_HUMAN
NCBI Protein Information
cathepsin K; cathepsin O; cathepsin O1; cathepsin O2; cathepsin X
NCBI Summary for CTSK
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]
Show more UniProt Comments for CTSK
CTSK: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Defects in CTSK are the cause of pycnodysostosis (PKND). PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. Belongs to the peptidase C1 family.
Protein type: EC 3.4.22.38; Protease
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: extracellular space; extracellular region
Molecular Function: collagen binding; proteoglycan binding; protein binding; fibronectin binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity
Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; intramembranous ossification; proteolysis involved in cellular protein catabolic process; toll-like receptor signaling pathway; innate immune response; proteolysis; bone resorption
Disease: Pycnodysostosis
Show more Protein type: EC 3.4.22.38; Protease
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: extracellular space; extracellular region
Molecular Function: collagen binding; proteoglycan binding; protein binding; fibronectin binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity
Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; intramembranous ossification; proteolysis involved in cellular protein catabolic process; toll-like receptor signaling pathway; innate immune response; proteolysis; bone resorption
Disease: Pycnodysostosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with CTSK assay kit
| Reference Product | PubMed Publications |
|---|---|
| NFATC1 assay kit | >44 publications with CTSK and NFATC1 |
| TLR3 assay kit | >1 publications with CTSK and TLR3 |
| TLR7 assay kit | >1 publications with CTSK and TLR7 |
| TLR9 assay kit | >1 publications with CTSK and TLR9 |
Pathways associated with CTSK assay kit
| Products by Pathway | Pathway Diagram |
|---|---|
| Activation Of Matrix Metalloproteinases Pathway antibodies | Activation Of Matrix Metalloproteinases Pathway Diagram |
| Adaptive Immune System Pathway antibodies | Adaptive Immune System Pathway Diagram |
| Collagen Degradation Pathway antibodies | Collagen Degradation Pathway Diagram |
| Degradation Of The Extracellular Matrix Pathway antibodies | Degradation Of The Extracellular Matrix Pathway Diagram |
| Extracellular Matrix Organization Pathway antibodies | Extracellular Matrix Organization Pathway Diagram |
| Immune System Pathway antibodies | Immune System Pathway Diagram |
| Innate Immune System Pathway antibodies | Innate Immune System Pathway Diagram |
| Lysosome Pathway antibodies | Lysosome Pathway Diagram |
| Lysosome Pathway antibodies | Lysosome Pathway Diagram |
| MHC Class II Antigen Presentation Pathway antibodies | MHC Class II Antigen Presentation Pathway Diagram |
Diseases associated with CTSK assay kit
| Disease Name | Pubmed Publications |
|---|---|
| Necrosis Antibodies | >58 publications with CTSK and Necrosis |
| Disease Models, Animal Antibodies | >55 publications with CTSK and Disease Models, Animal |
| Pycnodysostosis Antibodies | >52 publications with CTSK and Pycnodysostosis |
| Inflammation Antibodies | >45 publications with CTSK and Inflammation |
| Cardiovascular Diseases Antibodies | >32 publications with CTSK and Cardiovascular Diseases |
| Atherosclerosis Antibodies | >22 publications with CTSK and Atherosclerosis |
| Lung Diseases Antibodies | >22 publications with CTSK and Lung Diseases |
| Nervous System Diseases Antibodies | >19 publications with CTSK and Nervous System Diseases |
| Fibrosis Antibodies | >15 publications with CTSK and Fibrosis |
| Breast Neoplasms Antibodies | >15 publications with CTSK and Breast Neoplasms |
Organs/Tissues associated with CTSK assay kit
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Bone Antibodies | >495 publications with CTSK and Bone |
| Blood Antibodies | >137 publications with CTSK and Blood |
| Connective Tissue Antibodies | >111 publications with CTSK and Connective Tissue |
| Lung Antibodies | >41 publications with CTSK and Lung |
| Vascular Antibodies | >30 publications with CTSK and Vascular |
| Mouth Antibodies | >28 publications with CTSK and Mouth |
| Muscle Antibodies | >24 publications with CTSK and Muscle |
| Liver Antibodies | >22 publications with CTSK and Liver |
| Skin Antibodies | >16 publications with CTSK and Skin |
| Heart Antibodies | >16 publications with CTSK and Heart |