Altered MET expression has a well-established role in cancer development. The MET proto-oncogene normally regulates diverse physiological processes, including embryogenesis, wound healing, and immunomodulation, among others. However, abnormal MET expression promotes tumor invasion, angiogenesis, and metastasis. MET alterations are found across a wide spectrum of solid tumors, particularly non-small cell lung cancer (NSCLC) and gastric cancer.
Numerous oncogenic alterations in MET have been discovered, including exon 14 skipping mutations, activating mutations in the kinase domain, protein overexpression, and gene amplification. These alterations have been linked to higher histologic grade and advanced disease stage in their associated cancers. Understanding the clinical relevance of the these biomarkers has prompted much research into MET-targeted therapies.
Empire Genomics’ has developed a MET/Chromosome 7 FISH probe (picutred below) designed to detect MET copy number variations in blood and tissue samples. Our probes, which have been used by clinicians and researchers around the world, are available in both individual and large-scale lots, with customizable dye colors and a 3-year expiration date. We offer full customer support, with FISH specialists available to help with every step of FISH application.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
Gene Summary
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
Gene Details
Gene Symbol: MET
Gene Name: MET Proto-oncogene, Receptor Tyrosine Kinase
Chromosome: CHR7: 116312458-116438440
Locus: 7q31.2