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N-desmethyl Enzalutamide [1242137-16-1]

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Referência NB-64-09319-100mg

Tamanho : 100mg

Marca : Neo Biotech

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N-desmethyl Enzalutamide

(Synonyms: N-desmethyl MDV 3100) Copy Product Info

Synonyms: N-desmethyl MDV 3100

Catalog No. T19450 Copy Product Info

Purity: 99.74%

N-desmethyl Enzalutamide (N-desmethyl MDV 3100) is the active Enzalutamide metabolite.It is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide.

Cas No. 1242137-16-1

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.74%

Appearance:Solid

Color:White

Product Introduction

Bioactivity

Description	N-desmethyl Enzalutamide (N-desmethyl MDV 3100) is the active Enzalutamide metabolite.It is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide.
In vivo	N-desmethyl Enzalutamide, an active metabolite contributing to the clinical effects of Enzalutamide, circulates at similar plasma concentrations to Enzalutamide. The pharmacologically inactive carboxylic acid metabolite circulates at approximately 25% lower plasma concentrations than Enzalutamide [1].
Synonyms	N-desmethyl MDV 3100

Chemical Properties

Molecular Weight	450.41
Formula	C₂₀H₁₄F₄N₄O₂S
Cas No.	1242137-16-1
Smiles	CC1(C)N(C(=S)N(C1=O)c1ccc(C#N)c(c1)C(F)(F)F)c1ccc(C(N)=O)c(F)c1
Relative Density.	1.55 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (499.54 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (22.2 mM), Solution.

10% DMSO+90% Saline: < 10 mg/mL (22.2 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2202 mL	11.1010 mL	22.2020 mL	111.0100 mL
5 mM	0.4440 mL	2.2202 mL	4.4404 mL	22.2020 mL
10 mM	0.2220 mL	1.1101 mL	2.2202 mL	11.1010 mL
20 mM	0.1110 mL	0.5550 mL	1.1101 mL	5.5505 mL
50 mM	0.0444 mL	0.2220 mL	0.4440 mL	2.2202 mL
100 mM	0.0222 mL	0.1110 mL	0.2220 mL	1.1101 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

N-desmethyl MDV-3100N-desmethyl MDV3100N-desmethyl EnzalutamideNdesmethyl EnzalutamideN desmethyl EnzalutamideInhibitorinhibitAndrogen-receptorAndrogenReceptorAndrogen receptor

Related Tags: N-desmethyl Enzalutamide chemical structure | N-desmethyl Enzalutamide in vivo | N-desmethyl Enzalutamide formula | N-desmethyl Enzalutamide molecular weight