N-Palmitoyl dopamine [136181-87-8]

N-Palmitoyl dopamine (PALDA) is a endogenous, long-chain, linear fatty acid dopamide, which is inactive on TRPV1. N-Palmitoyl dopamine displays 'entourage' effects on endovanilloids N-arachidonoyl-dopamine (NADA) and anandamide^[1].

PALDA (0.1-10 μM), the EC₅₀ of N-arachidonoyl-dopamine (NADA) is lowered from approximately 90 to approximately 30 nM. The effect on intracellular Ca²⁺ by another endovanilloid, N-arachidonoyl-ethanolamine (anandamide, 50 nM), is also enhanced dose-dependently by PALDA. PALDA also acted in synergy with low pH (6.0-6.7) to enhance intracellular Ca²⁺ via TRPV1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

• [1]. Luciano De Petrocellis, et al. Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. Br J Pharmacol. 2004 Sep;143(2):251-6.  [Content Brief]