Tamanho : 10mg
Synonyms:
| Description | Notch1 (Notchhomolog 1, translocation-associated) encodes a protein that is a member of the NOTCH family. This type I transmembrane protein family is characterized by common structural features, including an extracellular domain made up of multiple epidermal growth factor-like (EGF) repeats and an intracellular domain composed of various types of domains. |
| In vitro | Notch 1 can enhance the survival and proliferation of mouse prostate cells by activating the pro-survival NF-κB pathway. In human prostate cancer cell lines, the suppression of Notch 1 and Jagged1 reduces invasion and cell growth in vitro. |
| Molecular Weight | 1500.72 |
| Formula | C62H97N15O22S3 |
| Cas No. | 2408730-51-6 |
| Smiles | [C@H](CC1=CC=CC=C1)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(O)=O)=O)CS)=O)[C@H](CC)C)=O)CS)=O)CCC(N)=O)=O)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CS)N)=O)CC(C)C)=O)CC(O)=O)=O)CCC(N)=O)=O)[C@H](CC)C)=O)=O)CCC(O)=O)=O |
| Sequence | Cys-Leu-Asp-Gln-Ile-Gly-Glu-Phe-Gln-Cys-Ile-Cys-Glu |
| Sequence Short | CLDQIGEFQCICE |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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