Palmitoyl 3-carbacyclic phosphatidic acid [476310-22-2]

Palmitoyl 3-carbacyclic phosphatidic acid (HY-139061) is a palmitoylated Carba-like cyclophosphatidic acid and an analog of lysophosphatidic acid (LPA). Palmitoyl 3-carbacyclic phosphatidic acid has different functions from LPA and can inhibit the activation of RhoA and inhibit the migration of melanoma cells. Palmitoyl 3-carbacyclic phosphatidic acid effectively inhibited experimental lung metastasis and reduced the number of tumor nodules in a B16-F0 xenograft mouse model^[1].

390.49

C₂₀H₃₉O₅P

476310-22-2

Solid

White to off-white

CCCCCCCCCCCCCCCC(OCC1CCP(O1)(O)=O)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Uchiyama A, et al. Inhibition of transcellular tumor cell migration and metastasis by novel carba-derivatives of cyclic phosphatidic acid. Biochim Biophys Acta. 2007 Jan;1771(1):103-12.  [Content Brief]