Rat TrxR1 (Thioredoxin Reductase 1) CLIA Kit
Referência MBS2531132-5x96
Tamanho : 5x96Tests
Marca : MyBiosource
Trxr1 (Thioredoxin Reductase 1) (TrxR1) CLIA Kit for Rat
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2531132Intended Uses: This CLIA kit applies to the in vitro quantitative determination of TrxR1 concentrations in serum, plasma and other biological fluids.Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit… More details
Product Overview
Online Datasheet in PDFProduct Name
TrxR1 (Thioredoxin Reductase 1), CLIA Kit
Full Product Name
Rat TrxR1 (Thioredoxin Reductase 1) CLIA Kit
Product Gene Name
TrxR1 clia kit
Product Synonym Names
TXNRD1; GRIM-12; TR; TR1; TXNR
Species Reactivity
Rat
Assay Type
Sandwich
Detection Range
31.25-2000pg/mL
Sensitivity
Min: 18.75pg/mL; Max: 2000pg/mL
Specificity
This kit recognizes natural and recombinant TrxR1. No significant cross-reactivity or interference between TrxR1 and analogues was observed.
Molecular Weight
50,873 Da
OMIM
601112
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of TrxR1 clia kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for TrxR1 purchase
MBS2531132 is a CLIA kit targeting TrxR1. Also known as Rat TrxR1 (Thioredoxin Reductase 1) CLIA Kit. Reactive in Rat.
Additional Details
NCBI/Uniprot data below describe general gene information for TrxR1. It may not necessarily be applicable to this product.
NCBI Official Full Name
thioredoxin reductase 1
NCBI Official Synonym Full Names
thioredoxin reductase 1
NCBI Official Symbol
TXNRD1
NCBI Official Synonym Symbols
TR; TR1; TXNR; TRXR1; GRIM-12
UniProt Protein Name
Thioredoxin reductase 1, cytoplasmic
UniProt Synonym Protein Names
Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1
UniProt Gene Name
TXNRD1
UniProt Synonym Gene Names
GRIM12; KDRF; TR; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein
UniProt Entry Name
TRXR1_HUMAN
NCBI Protein Information
thioredoxin reductase 1, cytoplasmic
NCBI Summary for TrxR1
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for TrxR1
TRXR1: a cytoplasmic pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine residue which is required for the catalytic activity.
Protein type: Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; EC 1.8.1.9; Oxidoreductase
Chromosomal Location of Human Ortholog: 12q23-q24.1
Cellular Component: nucleoplasm; mitochondrion; nucleolus; cytosol
Molecular Function: protein binding; thioredoxin-disulfide reductase activity; electron carrier activity; FAD binding; protein disulfide oxidoreductase activity
Biological Process: cell proliferation; transcription initiation from RNA polymerase II promoter; response to reactive oxygen species; mesoderm formation; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; cell redox homeostasis; gene expression; cellular lipid metabolic process; signal transduction
Show more Protein type: Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; EC 1.8.1.9; Oxidoreductase
Chromosomal Location of Human Ortholog: 12q23-q24.1
Cellular Component: nucleoplasm; mitochondrion; nucleolus; cytosol
Molecular Function: protein binding; thioredoxin-disulfide reductase activity; electron carrier activity; FAD binding; protein disulfide oxidoreductase activity
Biological Process: cell proliferation; transcription initiation from RNA polymerase II promoter; response to reactive oxygen species; mesoderm formation; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; cell redox homeostasis; gene expression; cellular lipid metabolic process; signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with TrxR1 clia kit
| Reference Product | PubMed Publications |
|---|---|
| TXN clia kit | >13 publications with TrxR1 and TXN |
| SEPHS2 clia kit | >2 publications with TrxR1 and SEPHS2 |
Pathways associated with TrxR1 clia kit
| Products by Pathway | Pathway Diagram |
|---|---|
| Cellular Responses To Stress Pathway antibodies | Cellular Responses To Stress Pathway Diagram |
| Detoxification Of Reactive Oxygen Species Pathway antibodies | Detoxification Of Reactive Oxygen Species Pathway Diagram |
| Disease Pathway antibodies | Disease Pathway Diagram |
| Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies | Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram |
| Gene Expression Pathway antibodies | Gene Expression Pathway Diagram |
| Generic Transcription Pathway antibodies | Generic Transcription Pathway Diagram |
| Infectious Disease Pathway antibodies | Infectious Disease Pathway Diagram |
| Metabolism Pathway antibodies | Metabolism Pathway Diagram |
| Metabolism Of Lipids And Lipoproteins Pathway antibodies | Metabolism Of Lipids And Lipoproteins Pathway Diagram |
| Metabolism Of Nucleotides Pathway antibodies | Metabolism Of Nucleotides Pathway Diagram |
Organs/Tissues associated with TrxR1 clia kit
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Liver Antibodies | >49 publications with TrxR1 and Liver |
| Blood Antibodies | >24 publications with TrxR1 and Blood |
| Lung Antibodies | >21 publications with TrxR1 and Lung |
| Kidney Antibodies | >15 publications with TrxR1 and Kidney |
| Brain Antibodies | >14 publications with TrxR1 and Brain |
| Heart Antibodies | >13 publications with TrxR1 and Heart |
| Muscle Antibodies | >13 publications with TrxR1 and Muscle |
| Vascular Antibodies | >11 publications with TrxR1 and Vascular |
| Prostate Antibodies | >10 publications with TrxR1 and Prostate |
| Skin Antibodies | >9 publications with TrxR1 and Skin |