Recombinant Mouse Interleukin-4 (IL-4) (CHO-expressed)

Biological Activity

Recombinant Mouse Interleukin-4 is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. It is produced by mast cells, activated T cells and bone marrow stromal cells. IL-4 regulates the differentiation of native CD4+ T cells (Th0 cells) into helper Th2 cells, and regulates the immunoglobulin class switching to the IgG1 and IgE isotypes. IL-4 also plays a major role in inflammation response and wound repair via activation of macrophage into M2 cells.

ED50 < 2 ng/ml, measured in a cell proliferation assay using murine HT-2 cells, corresponding to a specific activity of >5 x 10⁵ units/mg.

Accession: # P07750

Apparent Molecular Weight: ~15 kDa, on SDS-PAGE under reducing conditions.

Lyophilized after extensive dialysis against PBS.

Product Citations

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  Immun Inflamm Dis. 2023 Sep;11(9):e1011.

  Dendritic cells infected with recombinant adenoviral vector encoding mouse fibroblast activation protein-α and human livin α exert an antitumor effect against Lewis lung carcinoma in mice
  Recombinant Mouse Interleukin-4 (IL-4) (CHO-expressed) purchased from AbMole

Chemical Information

Solubility (25°C)	Reconstitute the lyophilized powder in ddH2O or PBS to a concentration not less than 100 μg/mL.
Storage	Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.