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> SOS1 Mouse Monoclonal Antibody [Clone ID: SOS-1]

SOS1 Mouse Monoclonal Antibody [Clone ID: SOS-1]

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Referência AM03036PU-N

Tamanho : 100ug


SOS1 Mouse Monoclonal Antibody [Clone ID: SOS-1]

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SKU
AM03036PU-N
SOS1 mouse monoclonal antibody, clone SOS-1, Aff - Purified
Size:
100 ug
Conjugation:
Unconjugated
 

View other "SOS1 or NP_005624" antibodies

Specifications
Product Data
Clone Name SOS-1
Application ELISA, IF, WB
Recommended Dilution Western Blotting under reducing conditions (1 µg/ml):
Positive control: HeLa human cervix carcinoma cell line.
Immunocytochemistry.
ELISA.
Reactivity Human, Mouse
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human Sos protein.
Specificity The antibody SOS-01 reacts with human Sos, an ubiquitously expressed 150 kDa intracellular protein.
Buffer PBS, pH 7.4 with 15 mM sodium azide as preservative.
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration lot specific
Purification Protein A affinity chromatography.
Conjugation Unconjugated
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid freeze/thaw cycles.
Stability Shelf life: One year from despatch.
Shipping Blue Ice
Gene Name SOS Ras/Rac guanine nucleotide exchange factor 1
Database Link
Background The guanine nucleotide exchange factor Sos (Son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization; the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.
Synonyms SOS-1, Son of sevenless homolog 1
Reference Data
Protein Categories Cytokines, Growth Factors, Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways Acute myeloid leukemia, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Dorso-ventral axis formation, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Focal adhesion, Gap junction, Glioma, GnRH signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway
Product Manuals
FAQs
  • Antibody and Western Standard
SDS

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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