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> Sterigmatocystine [10048-13-2]

Sterigmatocystine [10048-13-2]

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Referência HY-N6725-1mg

Tamanho : 1mg

Marca : MedChemExpress


Description

Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor[1][2]. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals[3].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
3.63 μM
Compound: 7
Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay
Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay
[PMID: 24251417]
MDA-MB-231 IC50
2.75 μM
Compound: 7
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by Alamar Blue assay
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by Alamar Blue assay
[PMID: 24251417]
NCI-H460 IC50
3.41 μM
Compound: 7
Cytotoxicity against human NCI-H460 cells after 72 hrs by Alamar Blue assay
Cytotoxicity against human NCI-H460 cells after 72 hrs by Alamar Blue assay
[PMID: 24251417]
PC-3M IC50
3.23 μM
Compound: 7
Cytotoxicity against human PC3M cells after 72 hrs by Alamar Blue assay
Cytotoxicity against human PC3M cells after 72 hrs by Alamar Blue assay
[PMID: 24251417]
SF-268 IC50
2.96 μM
Compound: 7
Cytotoxicity against human SF268 cells after 72 hrs by Alamar Blue assay
Cytotoxicity against human SF268 cells after 72 hrs by Alamar Blue assay
[PMID: 24251417]
In Vitro

Sterigmatocystine-induced DNA damage activates the ATM/53-dependent signaling pathway, which contributes to the induction of G2 arrest in GES-1 cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sterigmatocystine Related Antibodies
In Vivo

Sterigmatocystine (ip; 3 mg/kg once daily for 14 days) inhibits p21WAF1/CIP1[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Masse moléculaire

324.28

Formule

C18H12O6
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C2=C(OC3=C1C(O)=CC=C3)C4=C(O[C@]5(10)[C@@]4(10)C=CO5)C=C2OC
Structure Classification
Initial Source

Aspergillus versicolor
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvant et solubilité
In Vitro: 

DMSO : 25 mg/mL (77.09 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0838 mL 15.4188 mL 30.8375 mL
5 mM 0.6168 mL 3.0838 mL 6.1675 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureté et documentation
Références