TLR2 - human gene knockout kit via CRISPR, HDR mediated
Other products for "TLR2 or NM_001318787"
Specifications
Product Data
Format
2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector
RFP-BSD
Target Symbol
TLR2
Locus ID
7097
Components
KN207597G1, TLR2 gRNA vector 1 in pCas-Guide CRISPR vector
KN207597G2, TLR2 gRNA vector 2 in pCas-Guide CRISPR vector
KN207597RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.
GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer
These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jan 2016
TLR2 CRISPRa kit - CRISPR gene activation of human toll like receptor 2
1 kit
KN207597
TLR2 - human gene knockout kit via CRISPR, HDR mediated
1 kit
KN207597BN
TLR2 - human gene knockout kit via CRISPR, HDR mediated
1 kit
KN207597LP
TLR2 - human gene knockout kit via CRISPR, HDR mediated
1 kit
KN407597
TLR2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.
1 kit
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
