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> TLR4 (NM_138554) Human Tagged ORF Clone Lentiviral Particle

TLR4 (NM_138554) Human Tagged ORF Clone Lentiviral Particle

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Referência RC222820L3V

Tamanho : 200ul


TLR4 (NM_138554) Human Tagged ORF Clone Lentiviral Particle

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SKU
RC222820L3V
Lenti ORF particles, TLR4 (Myc-DDK tagged) - Human toll-like receptor 4 (TLR4), transcript variant 1, 200ul, >10^7 TU/mL
 

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Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol TLR4
Synonyms ARMD10; CD284; TLR-4; TOLL
Vector pLenti-C-Myc-DDK-P2A-Puro
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC222820).
ACCN NM_138554
ORF Size 2517 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_138554.2
RefSeq Size 5503 bp
RefSeq ORF 2520 bp
Locus ID 7099
UniProt ID O00206
Cytogenetics 9q33.1
Protein Families Druggable Genome, Transmembrane
Protein Pathways Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway
MW 95.7 kDa
Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Aug 2020

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