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Trigonelline [535-83-1]

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Referência NB-64-17984-25mg

Tamanho : 25mg

Marca : Neo Biotech

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Trigonelline

(Synonyms: Trigenolline) Copy Product Info

Synonyms: Trigenolline

Catalog No. T2887 Copy Product Info

Purity: 99.49%

Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.

Cas No. 535-83-1

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.49%

Color:White

Product Introduction

Bioactivity

Description	Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.
In vitro	Treatment of cells with Trigonelline attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9, and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells. Trigonelline significantly reduces the H2O2 induced necrosis and apoptosis in H9c2 cells. However, the further increment of Trigonelline concentration against H2O2 can induce the necrosis and apoptosis along with H2O2[1].
In vivo	Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength in nicotinamide/streptozotocin-treated rats. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders like intensify the osteoporotic changes in streptozotocin-treated rats and favorably affect bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats[2].
Synonyms	Trigenolline

Chemical Properties

Molecular Weight	137.14
Formula	C₇H₇NO₂
Cas No.	535-83-1
Smiles	C[n+]1cccc(c1)C([O-])=O
Relative Density.	1.2528 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 27.78 mg/mL (202.57 mM), Sonication is recommended.

DMSO: 7.5 mg/mL (54.69 mM), Sonication is recommended.

Ethanol: Insoluble

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	7.2918 mL	36.4591 mL	72.9182 mL	364.5909 mL
5 mM	1.4584 mL	7.2918 mL	14.5836 mL	72.9182 mL
10 mM	0.7292 mL	3.6459 mL	7.2918 mL	36.4591 mL
20 mM	0.3646 mL	1.8230 mL	3.6459 mL	18.2295 mL
50 mM	0.1458 mL	0.7292 mL	1.4584 mL	7.2918 mL

H2O

	1mg	5mg	10mg	50mg
100 mM	0.0729 mL	0.3646 mL	0.7292 mL	3.6459 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

TrigonellineInhibitorinhibitFerroptosisEndogenousMetaboliteEndogenous MetaboliteApoptosis

Related Tags: Trigonelline chemical structure | Trigonelline in vivo | Trigonelline in vitro | Trigonelline formula | Trigonelline molecular weight