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Venlafaxine [93413-69-5]

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Referência NB-64-11712-50mg

Tamanho : 50mg

Marca : Neo Biotech

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Venlafaxine

(Synonyms: Wy 45030) Copy Product Info

Synonyms: Wy 45030

Catalog No. T22453 Copy Product Info

Purity: 99.2%

Venlafaxine (Wy 45030), an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), is used to treat major generalised anxiety disorder (GAD), depressive disorder (MDD), panic disorder and social phobia.

Cas No. 93413-69-5

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.2%

Appearance:Solid

Color:White

Product Information

Venlafaxine AI Summary

Venlafaxine exhibits high affinity for the serotonin transporter (SERT) with a Ki value ranging from 8.9 nM to 52 nM, and moderate affinity for the norepinephrine transporter (NET) with Ki values spanning from 210 nM to 1623 nM. It shows weak binding to the dopamine transporter (DAT) with Ki values as high as 9300 nM. The compound functions as a potent inhibitor of both serotonin reuptake (IC50 = 20 nM to 323.59 nM) and norepinephrine reuptake (IC50 = 140 nM to 149.0 nM), with a significantly lesser effect on dopamine reuptake (IC50 > 1000 µM). Pharmacokinetically, it has moderate volume distribution (Vdss = 4.4 L.kg^-1) and exhibits high unbound fraction in plasma (Fu = 0.73). It is metabolically stable in human liver microsomes with intrinsic clearance (CL) of 59.0 mL.min^-1.g^-1. Venlafaxine has demonstrated antidepressant and anxiolytic activities in animal models, as well as an antiallodynic effect in nerve injury rats. Additionally, it shows good oral bioavailability in humans (Fa = 97%) and has moderate liver toxicity indicators. Venlafaxine does not cause severe drug-induced liver injury (DILI) and has displayed antiviral activity against SARS-CoV-2 in specific cellular assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Venlafaxine (Wy 45030), an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), is used to treat major generalised anxiety disorder (GAD), depressive disorder (MDD), panic disorder and social phobia.
Synonyms	Wy 45030

Chemical Properties

Molecular Weight	277.4018
Formula	C₁₇H₂₇NO₂
Cas No.	93413-69-5
Smiles	COC1=CC=C(C=C1)C(CN(C)C)C1(O)CCCCC1
Relative Density.	1.060 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245.00 mg/mL (883.20 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6049 mL	18.0244 mL	36.0488 mL	180.2440 mL
5 mM	0.7210 mL	3.6049 mL	7.2098 mL	36.0488 mL
10 mM	0.3605 mL	1.8024 mL	3.6049 mL	18.0244 mL
20 mM	0.1802 mL	0.9012 mL	1.8024 mL	9.0122 mL
50 mM	0.0721 mL	0.3605 mL	0.7210 mL	3.6049 mL
100 mM	0.0360 mL	0.1802 mL	0.3605 mL	1.8024 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

Wy-45030Wy45030VenlafaxineSLC6A4SERTSerotoninTransporterserotonin-norepinephrine reuptakeSerotonin TransporterserotoninreuptakenorepinephrineInhibitorinhibitantidepressant5-HTT5-HT

Related Tags: Venlafaxine chemical structure | Venlafaxine formula | Venlafaxine molecular weight