Tamanho : 1mg
Synonyms:
| Description | Verbascose is an oligosaccharide and non-reducing sugar that can regulate and enhance the immune function of RAW264.7 macrophages, increasing their proliferation activity, phagocytic activity, NO release, and cytokine secretion levels, and also has the potential to regulate intestinal microecological balance. |
| In vitro | Method: RAW264.7 cells were treated with different concentrations of Verbascose (25, 50, 100, 200, and 400 μg/mL) for 12, 24, 36, and 48 hours, and cell viability was assessed. Result: Verbascose significantly increased the viability of RAW264.7 cells in the range of 25–400 μg/mL in a time-dependent manner [1]. |
| In vivo | Methods: Immunosuppressed female Kunming mice were subcutaneously injected with different doses of Verbascose (30, 90, 120 mg/kg) once daily for 8 consecutive days. Results: Treatment with the medium dose (90 mg/kg) significantly increased the spleen index, lysozyme activity in the spleen and serum, serum hemolysin levels, and the earlap swelling rate in the delayed-type hypersensitivity (DTH) response. |
| Molecular Weight | 828.72 |
| Formula | C30H52O26 |
| Cas No. | 546-62-3 |
| Smiles | O([C@]1(CO)O[C@H](CO)[C@@H](O)[C@@H]1O)[C@H]2O[C@H](CO[C@H]3O[C@H](CO[C@H]4O[C@H](CO[C@H]5O[C@H](CO)[C@H](O)[C@H](O)[C@H]5O)[C@H](O)[C@H](O)[C@H]4O)[C@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O |
| Relative Density. | 1.86g/cm3 |
| Storage | Store at low temperature,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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