Reagentes e instrumentos para imunologia, biologia celular e biologia molecular.

α-Humulene [6753-98-6]

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Referência TN1373-25mg

Tamanho : 25mg

Marca : TargetMol

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α-Humulene (Synonyms: Alpha-caryophyllene)

α-Humulene

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Synonyms Alpha-caryophyllene

Cas No. 6753-98-6

For research use only—not for human use. No sales to individuals. Use as intended only.

Batch Information

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Purity:97.18%

Appearance:Liquid

Color:Transparent

Resource Download

COA HNMR GC

Product Introduction

Bioactivity

Description	α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory effects, probably by interfering with TNFalpha production and COX-2 and iNOS expression.
In vitro	S. officinalis essential oil was obtained by hydrodistillation and fractionated with column chromatography; the essential oil and its fractions were analyzed by gas chromatography (GC) coupled to mass spectrometry (MS). The cytotoxic activity was evaluated in cellular lines of breast cancer MCF-7, colon cancer HCT-116, and murine macrophage RAW264.7 cell lines by the MTT assay Results: the sub-subfraction F1.1.1 of S. officinalis essential oil containing alpha-humulene present highest activity on RAW264.7 and HCT-116 with IC(50) values of 41.9 and 77.3 mu g/ml, respectively. The sub-subfraction F1.2.1 of S. officinalis essential oil with trans-caryophyllene(Alpha-caryophyllene) showed less activity on RAW246.7 and HCT-116 with IC(50) values of 90.5 and 145.8 mu g/ml.
Synonyms	Alpha-caryophyllene

Chemical Properties

Molecular Weight	204.35
Formula	C₁₅H₂₄
Cas No.	6753-98-6
Smiles	C\C1=C/CC(C)(C)\C=C\C\C(C)=C\CC1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ether: Soluble

DMSO: 50 mg/mL (244.68 mM), Sonication is recommended.

Ethanol: Soluble

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (12.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8936 mL	24.4678 mL	48.9356 mL	244.6782 mL
5 mM	0.9787 mL	4.8936 mL	9.7871 mL	48.9356 mL
10 mM	0.4894 mL	2.4468 mL	4.8936 mL	24.4678 mL
20 mM	0.2447 mL	1.2234 mL	2.4468 mL	12.2339 mL
50 mM	0.0979 mL	0.4894 mL	0.9787 mL	4.8936 mL
100 mM	0.0489 mL	0.2447 mL	0.4894 mL	2.4468 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.