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| Gene : | Klrb1b |
| Gene ID : | 678513 |
| Uniprot ID : | Q5NKN4 |
| Alternative Name : | Klrb1b, Nkrp1b, Nkrp1c |
| Immunogen Information : | Splenic cells purified from the LEW rat |
CD161, also known as Nkrp1 (natural killer receptor protein 1) or Klrb1 (killer cell lectin-like receptor subfamily b member 1), is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.
| Subcellular location: | Membrane |
| Tissue Specificity: | Expressed in a subset of natural killer cells. |
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