General Info
Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit monoclonal antibody anti-OPRD1 (1-100) is suitable for use in Western Blot research applications. |
Clonality: | Monoclonal |
Clone ID: | S4MR |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | OPRD1 |
Gene ID: | 4985 |
Uniprot ID: | OPRD_HUMAN |
Immunogen Region: | 1-100 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human OPRD1 (P41143). |
Immunogen Sequence: | MEPAPSAGAELQPPLFANAS DAYPSACPSAGANASGPPGA RSASSLALAIAITALYSAVC AVGLLGNVLVMFGIVRYTKM KTATNIYIFNLALADALATS |
Description
Tissue Specificity | Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes. |
Post Translational Modifications | N-glycosylated. Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation.the ubiquitination is diminished by RTP4. |
Function | G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. |
Protein Name | Delta-Type Opioid ReceptorD-Or-1Dor-1 |
Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594Reactome: R-HSA-6785807 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
Alternative Antibody Names | Anti-Delta-Type Opioid Receptor antibodyAnti-D-Or-1 antibodyAnti-Dor-1 antibodyAnti-OPRD1 antibodyAnti-OPRD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance