Arachidonic acid [506-32-1]
Referência HY-109590-10mg
Tamanho : 10mg
Marca : MedChemExpress
Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid improves cognitive response and cardiovascular function.
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Arachidonic acid Chemical Structure
CAS No. : 506-32-1
This product is a controlled substance and not for sale in your territory.
Based on 16 publication(s) in Google Scholar
Other Forms of Arachidonic acid:
- Arachidonic acid-d8 In-stock
- Arachidonic acid-d5 In-stock
- Arachidonic acid-d11 In-stock
- Arachidonic acid sodium salt Obtenir un devis
- Arachidonic acid (Standard) Obtenir un devis
Description |
Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid improves cognitive response and cardiovascular function[1]. |
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IC50 & Target |
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In Vivo |
Arachidonic acid can be used in animal modeling to construct a rat paw edema model. Arachidonic acid (0.07%, 0.15% or 0.32% in diet; 4 weeks) increases Arachidonic acid content in the paw, but has no effect on arthritis severity and PGE2 content of the paw in a rat arthritis model[1]. Induction of Paw Edema Model[2]
Background
Principle: Injecting arachidonic acid into the hind paws of
rats can induce rapid and sustained inflammatory responses.
Specific Mmodeling Methods
Rats: Lewis • male • Administration: 0.5% • s.c. • single dose
Note
Injection method: A single subcutaneous injection of Arachidonic acid in the right hind paw of male Lewis rats (144-241 g) with an injection volume of 0.10 mL (Arachidonic acid is dissolved in 0.2 M carbonate buffer, pH 8.43-8.56 ).
Modeling Indicators
Appearance
Monitoring: Significant edema became apparent within 5 minutes, and
the reaction reached its peak at 1 hour after injection.
Opposite Product(s): Phenidone (HY-W010144); SK-F86002 (HY-12511) MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Essai clinique |
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Masse moléculaire |
304.47 |
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Formule |
C20H32O2 |
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CAS No. |
506-32-1 |
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Appearance |
Liquid |
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Color |
Colorless to light yellow |
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SMILES |
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O |
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Structure Classification |
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Initial Source |
mammalian cell |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
-20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) |
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Solvant et solubilité |
In Vitro:
Ethanol : 100 mg/mL (328.44 mM; Need ultrasonic) DMSO : 100 mg/mL (328.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Pureté et documentation |
Purity: 99.32% |
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Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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Ethanol / DMSO | 1 mM | 3.2844 mL | 16.4220 mL | 32.8440 mL | 82.1099 mL |
5 mM | 0.6569 mL | 3.2844 mL | 6.5688 mL | 16.4220 mL | |
10 mM | 0.3284 mL | 1.6422 mL | 3.2844 mL | 8.2110 mL | |
15 mM | 0.2190 mL | 1.0948 mL | 2.1896 mL | 5.4740 mL | |
20 mM | 0.1642 mL | 0.8211 mL | 1.6422 mL | 4.1055 mL | |
25 mM | 0.1314 mL | 0.6569 mL | 1.3138 mL | 3.2844 mL | |
30 mM | 0.1095 mL | 0.5474 mL | 1.0948 mL | 2.7370 mL | |
40 mM | 0.0821 mL | 0.4105 mL | 0.8211 mL | 2.0527 mL | |
50 mM | 0.0657 mL | 0.3284 mL | 0.6569 mL | 1.6422 mL | |
60 mM | 0.0547 mL | 0.2737 mL | 0.5474 mL | 1.3685 mL | |
80 mM | 0.0411 mL | 0.2053 mL | 0.4105 mL | 1.0264 mL | |
100 mM | 0.0328 mL | 0.1642 mL | 0.3284 mL | 0.8211 mL |
Arachidonic acid Related Classifications
- Metabolic Enzyme/Protease
- Endogenous Metabolite