dTRIM24 [2170695-14-2]
Referência T15178-5mg
Tamanho : 5mg
Marca : TargetMol
dTRIM24
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dTRIM24 is a selective bifunctional TRIM24 degradation agent based on PROTAC technology, consisting of the ligands von Hippel-Lindau and TRIM24.
Cas No. 2170695-14-2
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Purity:99.23%
Appearance:Solid
Color:White
COA HNMR LCMS
Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | dTRIM24 is a selective bifunctional TRIM24 degradation agent based on PROTAC technology, consisting of the ligands von Hippel-Lindau and TRIM24. |
| In vitro | dTRIM24 suppresses growth, accompanied by apoptosis measured as enhanced PARP cleavage.[1] dTRIM24 is a TRIM24 bromodomain degrader.[1] Recruitment of the VHL E3 ubiquitin ligase by dTRIM24 elicits potent and selective degradation of TRIM24.[1] |
| Molecular Weight | 1113.3 |
| Formula | C55H68N8O13S2 |
| Cas No. | 2170695-14-2 |
| Smiles | O(C1=C(NS(=O)(=O)C2=CC(C(NCCOCCOCCOCC(N[C@H](C(=O)N3[C@H](C(NCC4=CC=C(C=C4)C=5SC=NC5C)=O)C[C@@H](O)C3)C(C)(C)C)=O)=O)=CC=C2)C=C6C(=C1)N(C)C(=O)N6C)C7=CC(OCCC)=CC=C7 |
| Relative Density. | 1.316 g/cm3 (Predicted) |
| Storage | Store at low temperature,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: insoluble DMSO: 90 mg/mL (80.84 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (2.96 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||