Orb1310337-100mg | L-Ornithine [70-26-8] Clinisciences

L-Ornithine

SKU: orb1310337

Description

L-Ornithine is a non-proteinogenic amino acid that serves as a key intermediate in the urea cycle for nitrogen detoxification. Research applications include studying its renoprotective and anti-fatigue properties in metabolic, hepatic, and exercise physiology models, both in vivo and in vitro.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	70-26-8
MW	132.16
Purity	99.91% (May vary between batches)
Formula	C₅H₁₂N₂O₂
SMILES	NCCC[C@H](N)C(O)=O
Target	Amino Acids and Derivatives,Endogenous Metabolite,Arginase,Decarboxylase
Solubility	DMSO:Insoluble;H2O:50 mg/mL (378.33 mM)

Bioactivity

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Target IC50	Arginase (bovine):1.02 mM (Ki)
In Vivo	METHODS: To investigate the effect of L-Ornithine on peripheral clock gene expression, mice were orally treated with L-Ornithine (1000 mg/kg) for 3 days. RESULTS: The phase of PER2 gene expression in liver, submandibular gland and kidney was significantly advanced in L-Ornithine treated mice. METHODS: To investigate the effect of L-Ornithine on sleep behavior, L-Ornithine was added to the diet of maternal mice, and its effect on the sleep behavior of offspring mice was observed. RESULTS: L-Ornithine supplementation increased sleep-like behavior in mice. METHODS: To study the effect of L-Ornithine on acute necrotizing pancreatitis, rats were intraperitoneally injected with L-Ornithine (3 g/kg). RESULTS: Severe acute necrotizing pancreatitis was induced by L-Ornithine in rats.
In Vitro	METHODS: HK-2 cells were treated with L-Ornithine (100, 300 μM) for 24 hours, and ROS levels were measured using fluorescence microscopy. RESULTS: Ornithine protected HK-2 cells from ROS production.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Amino Acids and Derivatives, AminoAcidsandDerivatives, Arginase-1, Arginase-2, (S)-2,5-Diaminopentanoic acid, 2,5-Diaminopentanoic acid, Ornithine aminotransferase, Ornithine carbamoyltransferase, Ornithine decarboxylase antizyme 1, inhibit, L Ornithine, LOrnithine, L-Ornithine, Inhibitor, EndogenousMetabolite, Endogenous Metabolite

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pvdA Antibody [orb51690]
Applications:
ELISA, WB
Reactivity:
Bacteria
Species/Host:
Rabbit
Clonality:
Polyclonal
Conjugation:
Unconjugated
Sizes Available: 100 μg, 50 μg
Bacterial pvdA protein [orb358660]
Purity:
Greater than 90% as determined by SDS-PAGE.
MW:
65.5 kDa
Source:
E.coli
Sizes Available: 1 mg, 100 μg, 20 μg
Arginase Antibody [orb2638716]
Applications:
IHC-P
Reactivity:
Human
Species/Host:
Mouse
Clonality:
Monoclonal
Conjugation:
Unconjugated
Sizes Available: 7 ml