Ltbr rat monoclonal antibody, clone 5G11b, Low Endotoxin
Size:
500 ug
Conjugation:
Unconjugated
View other "Ltbr" antibodies
Specifications
Product Data
Clone Name
5G11b
Application
FC, FN
Recommended Dilution
Flow cytometry: 1/50 - 1/100. Functional assays.
Reactivity
Mouse
Antibody Host
Rat
Isotype
IgG2a
Clonality
Monoclonal
Immunogen
Recombinant extracellular domain of LT beta R
Specificity
This antibody recognises lymphotoxin-beta receptor (LT beta R), a member of the tumour necrosis factor family. LT beta R is primarily expressed on stromal cells and fibroblasts and at lower levels on myeloid cell lines. Clone 5G11b specifically recognises surface expressed LT beta R. The clone is reported to be agonistic with respect to NF Kappa B activation, MIP-2 induction and IL-6 release (2). This product is routinely tested by flow cytometry on mouse WEH1 cells.
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin alpha and lymphtoxin beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
