Mouse Ephb4 Antibody - middle region
Referência OAAB11045
Tamanho : 400ul
Marca : Aviva Systems Biology
Mouse Ephb4 Antibody - middle region (OAAB11045)
| Datasheets/Manuals | Printable datasheet for Mouse Ephb4 Antibody - middle region (OAAB11045) |
|---|
| Predicted Species Reactivity | Mouse |
|---|---|
| Product Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| Clonality | Polyclonal |
| Isotype | Ig |
| Host | Rabbit |
| Application | WB |
| Additional Information | Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis |
| :: | Cellular Location: Cell membrane; Single-pass type I membrane protein (By similarity) Tissue Location: Expressed in various organ systems, including lung, liver, kidney, intestine, muscle and heart |
| Reconstitution and Storage | Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | This Mouse Ephb4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-389 amino acids from the Central region of mouse Ephb4. |
| Purification | This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Predicted Homology Based on Immunogen Sequence | Mouse |
| Concentration | Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Intended Use | Mouse Ephb4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Application Info | WB: 1:1000 |
| Gene Symbol | Ephb4 |
|---|---|
| Alias Symbols | AI042935, b2b2412C, b2b2412Clo, developmental kinase 2, ephrin type-B receptor 4, hepatoma transmembrane kinase, Htk, mDK-2, MDK2, Myk1, Tyro, Tyro11, tyrosine kinase MYK-1. |
| NCBI Gene Id | 13846 |
| Protein Name | Ephrin type-B receptor 4|ephrin type-B receptor 4 isoform b precursor [Mus musculus] |
| Description of Target | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. |
| Uniprot ID | P54761 |
| Protein Accession # | https://www.ncbi.nlm.nih.gov/protein/NP_034274.4 |
| Molecular Weight | 108848 |
