Orb1223718-500mg | thymol [89-83-8] Clinisciences

thymol

SKU: orb1223718

Description

Thymol is a dye that is also known as 5-Methyl-2-(1-methylethyl)phenol.

Research Area

Pharmacology & Drug Discovery

Images & Validation

−

Key Properties

−

CAS Number	89-83-8
MW	150.22
Purity	>98% (HPLC)
Formula	C₁₀H₁₄O
SMILES	OC1=CC(C)=CC=C1C(C)C

Bioactivity

−

In Vivo	Animal model: orthotopic mouse LUAD model. Dosage: 75 mg/kg for Thymol, 10 mg/kg for anti‐PD‐1 antibody. Administration: anti‐PD‐1 antibody: i.p. , every 1 week from day 5 after tumor injection. Thymol: i.p. , every 2 days from day 5 after tumor injection. Result: Inhibited the progression of LUAD, and increased the survival of mice. Decreases IL4I1 level in tumors. Improved the efficacy of anti‐PD‐1 antibody.
In Vitro	Western blot analysis. Cell line: A549 cells. Concentration: 20 μM. Incubation time: 48 h. Result: Inhibited the protein levels of IL4I1, and the nuclear translocation of AHR.

In Vivo

Animal model: orthotopic mouse LUAD model. Dosage: 75 mg/kg for Thymol, 10 mg/kg for anti‐PD‐1 antibody. Administration: anti‐PD‐1 antibody: i.p. , every 1 week from day 5 after tumor injection. Thymol: i.p. , every 2 days from day 5 after tumor injection. Result: Inhibited the progression of LUAD, and increased the survival of mice. Decreases IL4I1 level in tumors. Improved the efficacy of anti‐PD‐1 antibody.

In Vitro

Western blot analysis. Cell line: A549 cells. Concentration: 20 μM. Incubation time: 48 h. Result: Inhibited the protein levels of IL4I1, and the nuclear translocation of AHR.

Storage & Handling

−

Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Thymol | NSC 11215 | NSC-11215 | NSC11215

−

Thymol [orb1478199]
CAS Number:
89-83-8
Sizes Available: 100 mg
4-Isopropyl-2-methylphenol.carousel__track {display: flex;} .carousel__track li {list-style: none;}.product-image {display: flex;align-items: center;}.product-image-wrapper {width: 21%;}.product-image-description {width: 90%;}#reviews {display: none;}

thymol [89-83-8]

Referência orb1223718-500mg

Marca : Biorbyt