5-Azacytidine
Referência OOAU00082-50MG
Tamanho : 50mg
Marca : Aviva Systems Biology
| Datasheets/Manuals | Printable datasheet for 5-Azacytidine (OOAU00082) |
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| Product Format | White powder |
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| Additional Information | Background: Incorporates into DNA, forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells. Methyltransferases in the presence of azacitidine incorporate it into DNA during replication and into RNA during transcription in the cell. Azacytidine acts as a false substrate and potent inhibitor of methyltransferases leading to reduction of DNA methylation. |
| :: | Features: DNA Methyltransferase inhibitor. Blocks cell cycle progression at G1. Induces activation of HIV-1 promoter |
| :: | CAS Number: 320-67-2 |
| :: | Chemical Formula: C8H12N4O5 |
| Reconstitution and Storage | RT |
| Alias Symbols | 4-Amino-1-b-D-ribofuranosyl-1,3,5-triazin-2(1H)-one |
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| Molecular Weight | 244.2 |