Voltage-gated potassium channel subunit beta-2 or Kvß2 is encoded by the gene KCNAB2. Kvß2 is a member of the potassium channel, voltage-gated, shaker-related subfamily. Kvβ2 is a cytoplasmic subunit that modulates the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on other channel proteins. Kvβ2 is expressed in brain, in thecerebellum and in the juxtaparanodal region of nodes of Ranvier. Kvβ2 expression is also detected in lung, heart and kidney. Diseases associated with KCNAB2 include Chromosome 1P36 Deletion Syndrome and Juvenile Amyotrophic Lateral Sclerosis 16,
Purified by Protein A chromatography
Lot dependent: provided at 0.6-1.0 mg/mL
Monoclonal
K17/70
IgG1
ELISA, ICC, IHC, WB
Mouse
Kcnab2 Ckbeta2 I2rf5 Kcnb3
38 kDa (major band), 41 kDa (minor band)
Fusion protein amino acids 1-367 (full length) of rat Kv2 (accession number NP_034728) produced recombinantly in E. Coli
Rat
Finch, Frog, Human, Mouse, Non-Human Primate, Rat, Xenopus, Zebrafish
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and buffer exchanged into 1X PBS. Purified mAbs are >90% specific antibody.
PBS
Unconjugated
No cross-reactivity reported
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
