Anti-PDGFRA Antibody (3I959)
Referência NB-64-122385-100uL
Tamanho : 100uL
Marca : Neo Biotech
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Anti-PDGFRA Antibody (3I959)
(Synonyms: platelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide) Copy Product InfoSynonyms: platelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide
Catalog No. TMAY-00970 Copy Product Info
Anti-PDGFRA Antibody (3I959) is a Mouse antibody targeting PDGFRA. Anti-PDGFRA Antibody (3I959) can be used in WB.
For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-PDGFRA Antibody (3I959) is a Mouse antibody targeting PDGFRA. Anti-PDGFRA Antibody (3I959) can be used in WB. |
| Synonyms | platelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide |
| Ig Type | Mouse IgG2a |
| Clone | 3I959 |
| Reactivity | Human |
| Specificity | Human PDGF alpha receptor/PDGFRA No cross-reactivity in ELISA with Human PDGFRb Human cell lysate (293 cell line) |
| Verified Activity | Anti-PDGFRa mouse monoclonal antibody at 1:500 dilution. -Lane A: 293T Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:123 kDa. -Observed band size:123 kDa |
| Application | WB |
| Recommended Dose | WB: 1:500-1:1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PDGFRA / CD140a (rh PDGFRA / CD140a; TMPY-01139; NP_006197.1; Met 1-Glu 524). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfamily of receptor tyrosine kinase (RTKs) with the similar structure characteristics of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGFRA is expressed in oligodendrocyte progenitor cells and mesothelial cell, and binds all three ligand isoforms PDGF-AA, PDGF-BB and PDGF-AB with high affinity, whereas PDGFRB dose not bind PDGF-AA. PDGFRA plays an essential role in regulating proliferation, chemotaxis and migration of mesangial cells. Recent studies have indicated that PDGFRA acts as a critical mediator of signaling in testis organogenesis and Leydig cell differentiation, and in addition, particularly important for kidney development. Additionally, PDGFRA is involved in tumor angiogenesis and maintenance of the tumor microenvironment and has been implicated in development and metastasis of Hepatocellular carcinoma (HCC). PDGFRA may represent a potential therapeutic target in thymic tumours. PDGFRA gene amplification rather than gene mutation may be the underlying genetic mechanism driving PDGFRA overexpression in a portion of gliomas.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human PDGFRA / CD140a protein (TMPY-01139) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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