Aucubin [479-98-1]
Referência NB-64-22034-10mg
Tamanho : 10mg
Marca : Neo Biotech
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Aucubin
(Synonyms: Rhinanthin, Aucuboside) Copy Product InfoSynonyms: Rhinanthin, Aucuboside
Catalog No. T3416 Copy Product Info
Purity: 99.83%
Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
Cas No. 479-98-1
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.83%
Color:White
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Product Information
Aucubin AI Summary
Aucubin exhibits a range of bioactivities, including inhibiting the classical complement pathway activation at 4 µM with significantly higher inhibition (89.3%) in the presence of beta glucosidase. It demonstrates potent inhibition of L3MBTL1 (63.1 nM) and induces DNA re-replication (183.6 nM) in SW480 colon adenocarcinoma cells. The compound also shows estrogenic activity at the ERalpha in human MVLN cells with activities of 81.25% and 99.1% at concentrations of 100 µg/mL and 20 µg/mL, respectively, compared to E2. It inhibits electric eel Acetylcholinesterase (AChE) and horse Butyrylcholinesterase (BChE) at 2 mg/mL, although the inhibition percentages are modest (-1.28% for AChE and -12.67% for BChE). Additionally, it exhibits moderate to high inhibitory activity against the COX1 enzyme (48.2% to 50.2%) but weaker activity against the COX2 enzyme (below 30%). It shows no significant cytotoxicity against various human cancer cell lines (IC50 > 10000 nM) and demonstrates minimal inhibitory effects against SARS-CoV-2 3CL-Pro protease (0.17% at 20 µM). Lastly, it exhibits 0.14% inhibition of SARS-CoV-2-induced cytotoxicity in VERO-6 cells at 10 µM concentration after 48 hours..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities. |
| Synonyms | Rhinanthin, Aucuboside |
| Molecular Weight | 346.33 |
| Formula | C15H22O9 |
| Cas No. | 479-98-1 |
| Smiles | OCC1OC(OC2OC=CC3C(O)C=C(CO)C23)C(O)C(O)C1O |
| Relative Density. | 1.61 g/cm3 |
| Storage | Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: 100 mg/mL (288.74 mM), Sonication is recommended.  H2O: Insoluble |
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.77 mM), Sonication is recommended. Please add the solvents sequentially, clarify
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