Orb1222210-200mg | Aucubin [479-98-1] Clinisciences

Aucubin

SKU: orb1222210

Description

Aucubin is an iridoid glycoside. Iridoids are commonly found in plants and function as defensive compounds. Irioids decrease the growth rates of many generalist herbivores. Aucubin was found to protect against liver damage induced by carbon tetrachloride or alpha-amanitin in mice and rats when 80 mg/kg was dosed intraperitoneally.

Images & Validation

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Key Properties

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CAS Number	479-98-1
MW	346.33
Purity	>98% (HPLC)
Formula	C₁₅H₂₂O₉
SMILES	C1=CO[C@H]([C@H]2[C@@H]1[C@@H](C=C2CO)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O
Target	IL-1β\| NF-κB
Solubility	DMSO : ≥ 31 mg/mL; 89.51 mM

Bioactivity

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In Vivo	Animal model: Male Wistar rats (200-230 g) induced diabetes by a injection of streptozotocin. Dosage: 5 mg/kg. Administration: i.p. twice daily for the first 5 days, followed by single injections daily for the last 10 days. Result: Increased the body weight of streptozotocin-diabetic rats. Lowered the blood glucose level. Decreased the level of lipid peroxidation and increased the activities of antioxidant enzymes. Increased in insulin immunoreactivity and the number of immunoreactive β cells compared with untreated diabetic rats.

In Vivo

Animal model: Male Wistar rats (200-230 g) induced diabetes by a injection of streptozotocin. Dosage: 5 mg/kg. Administration: i.p. twice daily for the first 5 days, followed by single injections daily for the last 10 days. Result: Increased the body weight of streptozotocin-diabetic rats. Lowered the blood glucose level. Decreased the level of lipid peroxidation and increased the activities of antioxidant enzymes. Increased in insulin immunoreactivity and the number of immunoreactive β cells compared with untreated diabetic rats.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Aucubin [orb1304221]
Purity:
97.16% (May vary between batches)
CAS Number:
479-98-1
MW:
346.33
Formula:
C₁₅H₂₂O₉
Sizes Available: 250 mg, 500 mg, 1 g
Catalpol [orb1225547]
Purity:
>98% (HPLC)
CAS Number:
2415-24-9
MW:
362.33
Formula:
C₁₅H₂₂O₁₀
Sizes Available: 50 mg, 100 mg, 200 mg, 500 mg, 1 g, 10 mg, 25 mg

Quick Database Links

Gene Symbol

IL-1β| NF-κB

Aucubin [479-98-1]

Referência orb1222210-200mg

Marca : Biorbyt