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> Nerol [106-25-2]

Nerol [106-25-2]

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Referência orb1301624-1ml

Tamanho : 1mlx10mM(inDMSO)

Marca : Biorbyt


Nerol

SKU: orb1301624

Description

Nerol is a monoterpene alcohol present in essential oils like lemon balm and hops. Research indicates it can mitigate ouabain-induced arrhythmias in mammalian hearts, making it a compound of interest for cardiovascular studies in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Images & Validation

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Nerol

Key Properties

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CAS Number106-25-2
MW154.25
Purity98.59% (May vary between batches)
FormulaC10H18O
SMILESC(\CCC=C(C)C)(=C\CO)/C
TargetEndogenous Metabolite|||Apoptosis|||Reactive Oxygen Species|||Mitochondrial Metabolism|||Antifungal
SolubilityDMSO:45 mg/mL (291.73 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (12.97 mM)

Bioactivity

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In Vivo
Nerol primarily by reducing Ca2+ influx through L-type Ca2+ channel blockade lessened the severity of ouabain-triggered arrhythmias in mammalian heart.
Animal Research
Guinea pigs were sacrificed by decapitation and hearts were removed and isolated left atrium mounted vertically in an organ baths containing Tyrode's solution of the following composition (mM): NaCl 120, KCl 2.7, MgCl2 0.9, NaHCO3 11.9, CaCl2 1.37, glucose 5.5, NaH2PO4 0.4, pH 7.4. The atria preparations were subsequently connected to Grass FI'-03 force displacement transducers to record changes in atrial contractile force. Each muscle was stretched to the length at which contractile force was maximal (1.0 gf). The atria were electrically paced at 1 Hz with pulses of 1.5 ms duration and stimulated by 70 V pulses. All preparations were allowed to equilibrate for 30 min until complete mechanical stabilization had been achieved. Nerol ( 97%) was freshly solubilized in 0.5% DMSO and cumulatively added to bath chambers. After each observation, muscles were washed several times and allowed to recover for 30 minutes until their mechanical function completely returned to control values. DMSO at this concentration did not show any significant effect on the variables measured (data not shown, n = 5).

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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ROS, Reactive Oxygen Species, ReactiveOxygenSpecies, Antifungal, Apoptosis, Calcium, dysfunction, Cis-Geraniol, MitochondrialMetabolism, mitochondrial, Mitochondrial Metabolism, Nerol, Neryl alcohol, NEL, inhibit, Fungal, Endogenous Metabolite, EndogenousMetabolite, Inhibitor
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  • Neryl acetate

    Neryl acetate [orb1297730]

    97.15% (May vary between batches)

    141-12-8

    196.29

    C12H20O2

    1 ml x 10 mM (in DMSO)
  • Nerol

    Nerol [orb1220847]

    >98% (HPLC)

    106-25-2

    154.25

    C10H18O

    10 mg, 25 mg, 50 mg, 100 mg, 500 mg, 1 g

Compound Identifiers

PubChem CID
643820 ↗

Key Properties

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Protocol Information