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> phospho-IKB epsilon (Ser157) Polyclonal Antibody, PE Conjugated

phospho-IKB epsilon (Ser157) Polyclonal Antibody, PE Conjugated

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Referência bs-5517R-PE

Tamanho : 100uL

Marca : Bioss


Applications

  • WB
  • IF(IHC-P)
  • IF(IHC-F)
  • IF(ICC)

Reactivity

  • Others

Predicted Reactivity

  • Human
  • Cow
Overview
Catalog # bs-5517R-PE
Product Name phospho-IKB epsilon (Ser157) Polyclonal Antibody, PE Conjugated
Applications WB, IF(IHC-P), IF(IHC-F), IF(ICC)
Reactivity Others
Predicted Reactivity Human, Cow
Specifications
Conjugation PE
Host Rabbit
Source KLH conjugated synthetic phosphopeptide derived from human NFKBIE around the phosphorylation site of Ser157
Modification Site Ser157
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 4794
Subcellular location Cytoplasm
Synonyms NFKBIE phospho S157; IKB epsilon Ser157; IKB epsilon S; p-IKB epsilon Ser157; p-IKB epsilon S157; I kappa B epsilon; IkappaBepsilon; IkB E; IKBE; IKB epsilon; MGC72568; NF kappa B inhibitor epsilon; NF kappa BIE; NFkappa BIE; NFkappaB inhibitor epsilon; NFKBIE; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor epsilon; OTTHUMP00000016522; Slc35b2; solute carrier family 35, member B2.
Background NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NFKB interaction with other transcription factors, such as STAT, AP1 (JUN), and NFAT.
Application Dilution
WB 1:300-5000
IF(IHC-P)
IF(IHC-F)
IF(ICC)